Takaitaccen Bayani:
Lambar CAS: 54965-21-8
Tsarin kwayoyin halitta: C12H15N3O2S
Nauyin kwayoyin: 265.333
Tsarin sinadarai:
Bayani
Albendazole (ALBENZA) wani nau'in anthelmintic ne mai fadi da ake gudanarwa ta baki.Albendazole wanda za a iya taunawa yana cikin jerin mahimman magunguna na Hukumar Lafiya ta Duniya (WHO) a matsayin maganin anthelminth na hanji da maganin filariya.Albendazole kwamfutar hannu ta SmithKline Animal Health Laboratories kuma ta amince da Cibiyar Abinci da Magunguna ta Amurka (FDA) a cikin 1996.
Albendazole yana da ikon kashe kwai na whipworm da hookworm gaba daya tare da kashe ƙwai Ascaris;Hakanan yana iya kawar da nau'ikan nematodes masu lalata a cikin jikin dabbobi, kuma yana da tasiri akan kawar da kai tsaye ko kashe tsutsotsi da cysticerci.Don haka yana da amfani a cikin maganin hydatid da tsarin juyayi (cysticercosis) wanda ke haifar da kamuwa da ƙwayar naman alade, da kuma maganin hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm da stercoralis nematode.
Pharmacodynamics
Albendazole wani nau'i ne na abubuwan da aka samo na benzimidazole.Yana da sauri metabolized a cikin vivo zuwa cikin sulfoxide, sulfone da 2-polyamine sulfone barasa.Yana iya zaɓi kuma ba tare da juyowa ba yana hana ɗaukar glucose na nematodes na hanji, don haka yana haifar da raguwar glycogen na tsutsa;A lokaci guda kuma, yana hana ayyukan fumarate reductase, don haka yana hana haɓakar adenosine triphosphate, a ƙarshe yana haifar da mutuwar parasites.
Kamar mebendazole, ta hanyar haifar da denaturation na cytoplasmic microtubules na hanji parasites da kuma ɗaure ga tubulin, shi ya haifar da toshe na cikin cell kai, haifar da tarawar Golgi endocrine barbashi;cytoplasm yana ƙara narkewa a hankali, yana haifar da mutuwar ƙarshe na parasites.
Wannan samfurin na iya kashe kwai tsutsotsi gaba ɗaya, ƙwan pinworm, qwai na ulu, qwai na tsutsotsi da ƙwayoyin bulala na cysticercosis da kashe ƙwai Ascaris.
Amfanin gama gari
Albendazole magani ne da ake amfani da shi don magance cututtukan da ƙwayoyin cuta ke haifarwa.Ana iya ba da shi don maganin ciwon ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (microsporidiosis).
Amfanin asibiti
Albendazole yana da nau'i mai fa'ida na aiki akan nematodes na hanji da cestodes, da kuma hanta na Opisthorchis sinensis, Opisthorchis viverrini, da Clonorchis sinensis.Hakanan an yi amfani da shi cikin nasara akan Giardia lamblia.Ana amfani dashi ko'ina cikin duniya don maganin kamuwa da ciwon intestinalnematode.Yana da tasiri a matsayin magani guda ɗaya don ascariasis, Sabbin cututtuka na hookworm, da kuma tsohuwar duniya.Magunguna da yawa tare da albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, da cutar hydatid.Tasirin albendazole antitapeworms (cestodes) gabaɗaya ya fi canzawa kuma ba ya da tasiri.Har ila yau, yana da tasiri a cikin maganin neurocysticercosis na kwakwalwa da na kashin baya, musamman idan aka ba da shi tare da dexamethasone. Ana ba da shawarar Albendazole don maganin gnathostomiasis.
