Takaitaccen Bayani:
Lambar CAS: 55268-74-1
Tsarin kwayoyin halitta: C19H24N2O2
nauyin kwayoyin: 312.41
Tsarin sinadarai:
| Bayanan asali | |
| Sunan samfur | Praziquantel |
| Daraja | Babban darajar Pharma |
| Bayyanar | Fari ne ko kusan fari crystalline foda |
| Assay | 99% |
| Rayuwar rayuwa | shekaru 2 |
| Shiryawa | 25kg/drum |
| Halaye | Mai narkewa da yardar kaina a cikin ethanol ko dichloromethane.Dan mai narkewa cikin ruwa |
| Sharadi | An rufe shi a bushe, adana a cikin injin daskarewa, ƙasa da -20 ° C |
Bayani
Praziquantel (PZQ) asalin isoquinoline ne tare da yawancin ayyukan nazarin halittu da aka samu a cikin levo eantiomer.Filin ba shi da wani aiki akan nematodes, amma yana da tasiri sosai akan cestodes da trematodes.
Pharmacology da tsarin aiki
Praziquantel wani fili ne na pyrazinoquinoline wanda aka samo asali don maganin schistosomiasis amma an same shi yana da faffadan ayyukan anthelminthic.Praziquantel abokin tsere ne amma R (+) enantiomer shine ke da alhakin ayyukan antiparasitic.Yana aiki a kan trematodes (duk nau'in Schistosoma pathogenic ga mutum, Paragonimus westermani, da Clonorchis sinensis) da cestodes (Taenia saginata, Taenia solium, Hymenolepis nana da Diphyllobothrium latum).
Ba a san tsarin aikin praziquantel a fili ba.Schistosomes suna shan maganin da sauri.Shaye-shayen miyagun ƙwayoyi yana biye da shi nan da nan tare da ƙara yawan aikin tsoka wanda ke haifar da raguwar tetanic da ɓarna daga tegument na parasite.
Ana tsammanin tasirin muscular na miyagun ƙwayoyi yana da alhakin jujjuyawar ƙwayoyin cuta daga veins na mesenteric zuwa hanta a cikin vivo.Koyaya, an nuna canjin hanta tare da mafi yawan sanannun schistosomicides kuma maiyuwa ba zai ba da takamaiman takamaiman tsarin aikin maganin ba.Sakamakon gwaji na baya-bayan nan ya nuna cewa tasirin antischistosomal na miyagun ƙwayoyi yana da alaƙa da tasirin sa akan tegument maimakon a kan musculature.
Wani sakamako na pharmacological na miyagun ƙwayoyi ya haɗa da haɓakar haɓakar membrane zuwa cations, musamman alli.
Duk da haka, rawar da wannan tasiri ya haifar ga dukiyar anthelminthic na miyagun ƙwayoyi ba a sani ba.
Aikace-aikace
Wani nau'i ne na maganin cututtukan cututtuka masu faɗi.Ana iya amfani dashi don magani da rigakafin schistosomiasis, cysticercosis, paragonimiasis, hydatid cuta, fasciolopsiasis, cutar hydatid, da kamuwa da tsutsa.
Hakanan za'a iya amfani dashi azaman anthelmintic kuma yana da tasiri wajen magance nematodes na ciki na dabba.Ana iya haɗa shi a cikin abinci don aikace-aikacen.
Samfurin wani nau'i ne na maganin anthelmintic mai tasiri wajen magance Schistosoma japonicum, Schistosoma mansoni da Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms da cysticercosis.Yana da tasirin kisa musamman akan tapeworm kuma a halin yanzu yana da inganci mafi inganci tsakanin maganin schistosomiasis.
Wani nau'in maganin anthelmintic ne wanda aka fi amfani dashi don magance schistosomiasis.Hakanan ana iya amfani dashi don magance Fahrenheit schistosomiasis, taeniasis, paragonimiasis, da cysticercosis.
