Takaitaccen Bayani:
Lambar CAS: 472-15-1
Tsarin kwayoyin halitta:C30H48O3
nauyin kwayoyin: 456.71
Tsarin sinadarai:
| Bayanan asali | |
| Sunan samfur | Betulinic acid |
| Daraja | Babban darajar Pharma |
| Bayyanar | Fari ko fari |
| Assay | 98% |
| Rayuwar rayuwa | shekaru 2 |
| Shiryawa | 25kg/drum |
| Sharadi | Barga, amma adana sanyi. Ba tare da jituwa tare da magungunan oxidizing mai ƙarfi, alli gluconate, barbiturates, magnesium sulfate, phenytoin, bitamin na rukunin B na sodium. |
Bayani
Betulinic acid (472-15-1) shine Lupane triterpenoid na halitta daga farin bishiyar birch (Betula pubescens). Yana haifar da apoptosis a cikin layukan tantanin halitta iri-iri.1 Yana haifar da mitochondrial permeability miƙa mulki buɗewa.2
Amfani
Betulinic acid shine triterpenoid pentacyclic na halitta. Betulinic acid yana nuna aikin anti-inflammatory da anti-HIV. Betulinic acid yana haifar da apoptosis a cikin ƙwayoyin ƙari ta hanyar kunna hanyar mitochondrial na apoptosis kai tsaye ta hanyar p53- da CD95 mai zaman kanta. Betulinic acid kuma yana nuna ayyukan agonist na TGR5.
An yi amfani da Betulinic acid (BetA):
1.don gwada tasirin sa a matsayin wakili na antiviral akan cutar Dengue (DENV).
2.as a sterol regulatory element-binding protein (SREBP) inhibitor don danne lipid metabolism da kuma yaduwa na fili cell renal cell carcinoma (ccRCC) Kwayoyin.
3.a matsayin magani don gwada abubuwan da ke hana kumburin ƙwayar cuta don iyawar tantanin halitta da ƙididdigar mutuwar kwayar cutar apoptotic a cikin nau'ikan myeloma da yawa.
Binciken Anticancer
Wannan fili shine triterpene pentacyclic da aka samu daga nau'in Betula da Zizyphus, wanda ke nuna zaɓin cytotoxicity akan ƙwayoyin melanoma na ɗan adam (Shoeb2006). Yana haifar da nau'in oxygen mai amsawa, yana kunna MAPK cascade, inhibitstopoisomerase I, yana hana angiogenesis, yana daidaita masu haɓaka haɓakar haɓakawa, yana daidaita ayyukan aminopeptidase-N, kuma ta haka ya haifar da sapoptosis a cikin ƙwayoyin kansa (Desai et al. 2008; Fulda 2008).
Ayyukan Halittu
Triterpenoid na halitta wanda ke nuna anti-HIV da aikin antitumor. Yana haifar da samar da nau'in oxygen mai amsawa (ROS) kuma yana kunna NF-κ B. Yana nuna aikin TRG5 agonist (EC 50 = 1.04 μ M).
Ayyukan Biochem/physiol
Betulinic acid, triterpene pentacyclic, yana zaɓar apoptosis a cikin ƙwayoyin tumo ta hanyar kunna hanyar mitochondrial na apoptosis kai tsaye ta hanyar p53- da CD95 mai zaman kanta.
