Takaitaccen Bayani:
Lambar CAS: 1264-72-8
Tsarin kwayoyin halitta: 2 (C52H98N16O13).5 (H2SO4)
Nauyin kwayoyin: 2801.27
Tsarin sinadarai:
| Bayanan asali | |
| Sunan samfur | Colistin sulfate |
| Daraja | Matsayin Ciyarwa |
| Bayyanar | Fari ko kusan fari, hygroscopic foda |
| Assay | 99% |
| Rayuwar rayuwa | shekaru 2 |
| Shiryawa | 20kg/kwali 20kg/drum |
| Sharadi | Adana a -20 ℃ na shekara guda (foda) |
Bayanin samfurin
Colistin shine decapeptide na cyclic cationic wanda ke da alaƙa da sarkar gefen fatty acid, yana cikin rukuni na peptides na ƙwayoyin cuta masu tsari iri ɗaya.Colistin sulfate shine maganin rigakafi na polypeptide wanda ke hana kwayoyin cutar gram-korau ta hanyar ɗaure ga lipopolysaccharides da phospholipids a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
Colistin sulfate, wanda kuma aka sani da colistin sulfate, Christian (Colistin), Polymyxin E (Polymyxin E), antiphytin, fari ko kusan fari foda, wari, ɗanɗano ɗanɗano mai ɗanɗano, mai sauƙin narkewa cikin ruwa, ɗan narkewa a cikin methanol, ethanol, kusan insoluble a ciki. acetone, ether, alkali kyauta dan kadan mai narkewa a cikin ruwa.Barga a cikin kewayon PH3-7.5.Mycolistin sulfate yana samar da Bacillus polymyxoides, wanda ke da tasiri mai karfi na antibacterial akan kwayoyin gram-korau.Ana amfani da shi don magance cututtukan hanji da ƙwayoyin cuta na gram-korau ke haifarwa, kuma ana amfani da ita azaman ƙari na ciyarwa tare da ingantaccen tasirin haɓaka haɓaka.Haɗin tasirin sulfadiazine ya fi kyau.
Aiki na samfur
Colistin sulfate granules sun inganta a cikin kwanciyar hankali na ƙarfi a cikin abinci da kuma nuna babban solubility duk da ana samar da su ba tare da amfani da wani mai ɗaukar kaya mai tsada ko kayan aiki na musamman ba.Musamman, colistin sulfate granules kunshi da gaske na colistin sulfate da ciwon barbashi diamita na 150 zuwa 1500m, wani takamaiman surface yanki na 40 zuwa 500 cm2/g, wani wetting lokaci na 5 minutes ko kasa da danshi abun ciki na 10 % ko kasa.
Pharmacodynamics
Colistin shine maganin rigakafi na polymyxin.Polymyxins su ne cationic polypeptides waɗanda ke rushe membrane na kwayan cuta ta hanyar kayan wanka.Tare da haɓakar ƙananan abubuwa masu guba, irin su penicillins mai tsayi da cephalosporins, amfani da parenteral polymyxin an yi watsi da shi sosai, sai dai don kula da cututtukan cututtukan huhu da yawa a cikin marasa lafiya tare da cystic fibrosis.
