Cefradine

Cefradine (kuma aka sani da cephradine), 7-[D-2-amino-2(1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 shine maganin rigakafi na cephalosporin Semi-synthetic. ana amfani da shi ta baki, a cikin jiki, da kuma cikin jijiya. Tsarin cephradine yayi kama da na cephalexin, kawai bambanci shine a cikin zobe mai memba shida. Cephalexin yana da uku. biyu bond forming wani aromatic tsarin yayin da cephradine yana da biyu bond biyu a cikin wannan zobe^[1].

Hoto1 tsarin sinadarai na cefradine;
Cephradine shine farin crystalline foda tare da nauyin kwayoyin 349.4^[2]. An tattauna kira na cephradine^[3]. Cephradine yana narkewa cikin yardar kaina a cikin kaushi mai ruwa. Zwitterion ne, wanda ya ƙunshi duka rukunin amino acid na alkaline da ƙungiyar carboxyl acidic. A cikin kewayon pH na 3-7, cephradine yana kasancewa azaman gishiri na ciki^[4]. Cephradine yana da kwanciyar hankali don 24 hr a 25 "a cikin kewayon pH na 2-8. Tun da yake yana da kwanciyar hankali a cikin kafofin watsa labaru na acidic, akwai ƙananan asarar aiki a cikin ruwan ciki; asarar kasa da 7% an ruwaito.^[5].
Cephradine yana da rauni a raunata da sunadaran jini na ɗan adam. Maganin ya kasance ƙasa da 20% ɗaure ga sunadaran jini^[4]. A cikin ƙwayar jini na 10-12 pg / ml, 6% na jimlar miyagun ƙwayoyi ya kasance a cikin hadaddun furotin. Wani nazari^[6]gano cewa a cikin jimlar 10 pg / ml, 28% na miyagun ƙwayoyi ya kasance a cikin yanayin da ke da alaƙa; a cikin jimlar 100 pg / ml, 30% na miyagun ƙwayoyi ya kasance a cikin yanayin da aka ɗaure da furotin. Har ila yau, wannan binciken ya nuna cewa ƙara da magani ga cephradine ya rage yawan aikin rigakafi. Wani nazari^[2]ya nuna cewa haɗin furotin na cephradine ya bambanta daga 8 zuwa 20%, dangane da ƙaddamar da miyagun ƙwayoyi. Koyaya, binciken da Gadebusch et al.^[5]Ba a sami wani canji a cikin MIC na cephradine zuwa ko dai Staphylococcus aureus ko Escherichia coli ba bayan ƙarin maganin ɗan adam.