Takaitaccen Bayani:
Lambar CAS: 15687-27-1
Tsarin kwayoyin halitta: C13H18O2
Nauyin Kwayoyin: 206.28
Tsarin sinadaran:
| Bayanan asali | |
| Sunan samfur | Ibuprofen |
| CAS No. | 15687-27-1 |
| Launi | Fari zuwa fari-fari |
| Siffar | Crystalline Foda |
| Solubility | A zahiri wanda ba a iya narkewa cikin ruwa, mai narkewa da yardar rai a cikin acetone, a cikin methanol da a cikin methylene chloride. Yana narkar da a tsarma mafita na alkali hydroxides da carbonates. |
| Ruwan Solubility | marar narkewa |
| Kwanciyar hankali | Barga. Mai ƙonewa. Wanda bai dace ba tare da magunguna masu ƙarfi masu ƙarfi |
| Rayuwar Rayuwa | 2 Ykunnuwa |
| Kunshin | 25kg/Drum |
Bayani
Ibuprofen yana cikin maganin analgesic wanda ba steroidal anti-inflammatory ba. Yana da kyau kwarai anti-mai kumburi, analgesic da antipyretic sakamako tare da m m halayen. An yi amfani da shi sosai a duniya, a matsayin mafi kyawun sayar da magungunan da ba sa sayan magani a duniya. Shi, tare da aspirin da paracetamol an jera su a matsayin samfuran maganin analgesics guda uku masu mahimmanci na antipyretic. A kasar mu, an fi amfani da shi wajen rage radadin ciwo da kuma maganin rheumatism da dai sauransu. Yana da karancin amfani da shi wajen maganin mura da zazzabi idan aka kwatanta da paracetamol da aspirin. Akwai da yawa na kamfanonin harhada magunguna da suka cancanci samar da ibuprofen a China. Amma yawancin tallace-tallacen kasuwannin cikin gida na ibuprofen sun mamaye kamfanin Tianjin Sino-US.
Dr. Stewart Adams ya gano Ibuprofen (daga baya ya zama farfesa kuma ya lashe Medal na Birtaniya) da tawagarsa ciki har da CoLinBurrows da Dr. John Nicholson. Manufar binciken farko shine samar da "super aspirin" don samun madadin maganin rheumatoid amosanin gabbai wanda yayi kama da na aspirin amma tare da mummunan halayen. Ga wasu magunguna irin su phenylbutazone, yana da babban haɗari na haifar da hana adrenal da sauran abubuwan da ba su da kyau kamar ciwon ciki. Adams ya yanke shawarar neman magani tare da juriya mai kyau na gastrointestinal, wanda ke da mahimmanci musamman ga duk magungunan da ba steroidal anti-inflammatory ba.
Magungunan Phenyl acetate sun tayar da sha'awar mutane. Ko da yake an gano wasu daga cikin wadannan magungunan suna cikin haɗarin haifar da gyambon ciki bisa gwajin da kare ya yi, Adams ya san cewa wannan al'amari na iya kasancewa saboda tsawon rabin rayuwar maganin. A cikin wannan nau'in kwayoyi akwai fili - ibuprofen, wanda ke da ɗan gajeren rabin rayuwa, yana ɗaukar sa'o'i 2 kawai. Daga cikin madadin magungunan da aka tantance, kodayake ba shine mafi inganci ba, shine mafi aminci. A cikin 1964, ibuprofen ya zama mafi kyawun madadin aspirin.
Alamomi
Manufar gama gari a cikin ci gaban magungunan zafi da kumburi shine ƙirƙirar mahadi waɗanda ke da ikon magance kumburi, zazzabi, da zafi ba tare da rushe sauran ayyukan ilimin lissafi ba. Maganganun zafi na gaba ɗaya, irin su aspirin da ibuprofen, suna hana duka COX-1 da COX-2. Ƙayyadaddun magani ga COX-1 da COX-2 yana ƙayyade yuwuwar illar illa. Magunguna da ke da ƙayyadaddun ƙayyadaddun abubuwa zuwa COX-1 za su sami babban yuwuwar haifar da illa masu illa. Ta hanyar kashe COX-1, masu rage zafin da ba zaɓaɓɓu ba suna ƙara damar samun sakamako mara kyau, musamman matsalolin narkewa kamar ciwon ciki da zub da jini na ciki. Masu hana COX-2, kamar Vioxx da Celebrex, zaɓin kashe COX-2 kuma ba sa cutar da COX-1 a matakan da aka tsara. COX-2 inhibitors an wajabta yadu don maganin arthritis da jin zafi. A cikin 2004, Hukumar Abinci da Magunguna (FDA) ta sanar da cewa haɗarin bugun zuciya da bugun jini yana da alaƙa da wasu masu hana COX-2. Wannan ya haifar da lakabin gargaɗi da kuma cire samfuran daga kasuwa da son rai daga masu kera magunguna; alal misali, Merck ya ɗauki Vioxx daga kasuwa a cikin 2004. Ko da yake ibuprofen ya hana duka COX-1 da COX-2, yana da sau da yawa ƙayyadaddun zuwa COX-2 idan aka kwatanta da aspirin, yana haifar da ƙananan sakamako masu illa na gastrointestinal..
