Cefoperezone sodium + sulbactam sodium

Bayani:
Cefoperazone sodium + sulbactam sodium (1: 1/2: 1) wani mahaifa ne mai aiki, mai hana β-lactamase kwanan nan an gabatar da shi azaman 1: 1 samfurin haɗin gwiwa tare da cefoperazone. Kamar clavulanic acid, wakili na farko na wannan nau'in da za a gabatar, sulbactam yana haɓaka tasirin maganin rigakafi na β-lactam akan nau'ikan juriya.
Amfani:
Semi-synthetic β-lactamase inhibitor. Ana amfani dashi a hade tare da maganin rigakafi na β-lactam azaman antibacterial.
Cefoperazone sodium gishiri shine maganin rigakafi na cephalosporin don hana rMrp2-matsakaici [3H] E217βG tare da IC50 na 199 μM. Manufa: Cefoperazone Antibacterial bakararre ce, semisynthetic, m-bakan, kwayoyin cephalosporin parenteral don gudanarwar cikin jini ko na cikin tsoka. Bayan gudanarwar cikin jijiya na 2 g na Cefoperazone, matakan da ke cikin jini sun tashi daga 202μg/mL zuwa 375 μg/mL dangane da lokacin gudanar da magani. Bayan allurar intramuscularly na 2 g na Cefoperazone, matsakaicin matsakaicin matakin ƙwayar jini shine 111 μg/ml a 1.5 hours. A sa'o'i 12 bayan yin allurai, ma'anar matakan jini har yanzu suna 2 zuwa 4 μg/mL. Cefoperazone yana da kashi 90 cikin dari na sunadaran jini.