Takaitaccen Bayani:
Lambar CAS:590-63-6
Tsarin kwayoyin halitta:C7H17ClN2O2
nauyin kwayoyin:196.68
Tsarin sinadarai:
| Bayanan asali | |
| Sunan samfur | Bethanechol |
| Daraja | Babban darajar Pharma |
| Bayyanar | farin foda |
| Assay | 95% |
| Rayuwar rayuwa | shekaru 2 |
| Shiryawa | 25kg/drum |
| Sharadi | Sanyi da bushe wuri |
Bayani
Bethanechol shine ester na roba da aka tsara da kuma ilimin likitanci dangane da acetylcholine. A sannu a hankali hydrolyzed muscarin agonist ba tare da nicotinic effects, bethanechol gabaɗaya ana amfani da don ƙara santsi tsoka sautin, kamar yadda a cikin GI fili bin ciki tiyata ko a cikin fitsari riƙewa a cikin rashin toshewa. Yana iya haifar da hypotension, canje-canje na zuciya, da spasms na bronchial.
Bethanechol ne agonist na muscarinic acetylcholine receptors tare da IC50 dabi'u na 1,837, 25, 631, 317, da kuma 393 μM ga M1-5, bi da bi, a cikin wani radioligand dauri assay ta amfani da CHO Kwayoyin bayyana dan Adam masu karɓa. Yana hana haɓakawar M2-matsakaici a cikin AMP na cyclic wanda ya haifar da isoproterenol a cikin ƙananan hanji na alade (IC50 = 127 μM). Bethanechol yana ƙara sautin basal na ureter na intravesical keɓaɓɓe (EC50 = 4.27 μM). Hakanan yana haifar da ɓoyewar ruwa a cikin ileum, duodenum, da jejunum na berayen anesthetized lokacin da aka gudanar a kashi na 60 μg/kg. An yi amfani da nau'ikan da ke ɗauke da bethanechol don ƙara yawan fitsari da kuma inganta sautin tsoka mai santsi a cikin sashin gastrointestinal.
Amfanin asibiti
Babban amfani da bethanechol chloride shine a cikin sauƙi na riƙewar fitsari da ƙumburi na ciki bayan tiyata. Ba dole ba ne a taɓa gudanar da shi ta hanyar intramuscular ko alluran jijiya saboda haɗarin cholinergic overtimulation da asarar zaɓin zaɓi. Gudanar da maganin da ya dace yana da alaƙa da ƙarancin guba kuma babu wani mummunan tasiri. Ya kamata a yi amfani da chloride na Bethanechol tare da taka tsantsan marassa lafiya inasthmatic; lokacin da aka yi amfani da shi don glaucoma, yana haifar da ciwon kai na gaba daga maƙarƙashiya na sphinctermuscle a cikin ido da kuma daga ciliary tsoka spasms. Tsawon aikinsa shine awa 1.
Magungunan Dabbobi da Magunguna
A cikin magungunan dabbobi, ana amfani da bethanechol da farko don tayar da ƙwayar mafitsara a cikin ƙananan dabbobi. Hakanan za'a iya amfani dashi azaman abin motsa jiki ko na GI na gabaɗaya, kodayake metoclopramide da / ko neostigmine sun maye gurbin shi don waɗannan amfani.
