Takaitaccen Bayani:
Lambar CAS: 7177-48-2
Tsarin kwayoyin halitta: C16H25N3O7S
Nauyin kwayoyin: 403.45
Tsarin sinadarai:
| Bayanan asali | |
| Sunan samfur | Ampicillin |
| Daraja | Matsayin Magunguna |
| Bayyanar | Fari ko kusan fari, lu'ulu'u foda |
| Assay | |
| Rayuwar rayuwa | Shekaru 2 |
| Shiryawa | 25kg/drum |
| Sharadi | adana a cikin sanyi da bushe wuri |
Bayani
A matsayin rukuni na penicillin na maganin rigakafi na beta-lactam, Ampicillin shine farkon nau'in penicillin mai fa'ida, wanda ke aiki a cikin vitro akan ƙwayoyin cuta na gram-positive da gram-negative aerobic da anaerobic, wanda akafi amfani dashi don rigakafi da magance cututtukan ƙwayoyin cuta na ƙwayoyin cuta na numfashi, urinary. fili, tsakiyar kunne, sinuses, ciki da hanji, mafitsara, da koda, da sauransu. Ana kuma amfani da ita don magance cutar gonorrhea maras rikitarwa, ciwon sankarau, endocarditis salmonellosis, da sauran cututtuka masu tsanani ta hanyar baki, allurar ciki ko ta hanyar jiko. Kamar duk maganin rigakafi, ba shi da tasiri don maganin cututtukan cututtuka.
Ampicillin yana aiki ta hanyar kashe ƙwayoyin cuta ko hana girma. Bayan shiga Gram-positive da Gram-negative kwayoyin cuta, yana aiki a matsayin mai hanawa na enzyme transpeptidase da kwayoyin ke buƙata don yin bangon tantanin halitta, wanda ke haifar da hana haɗin bangon tantanin halitta kuma a ƙarshe yana haifar da lysis na cell.
Ayyukan antimicrobial
Ampicillin ba shi da ɗan ƙaranci fiye da benzylpenicillin akan yawancin ƙwayoyin cuta na Gram amma ya fi aiki da E. faecalis. MRSA da nau'in Str. ciwon huhu tare da rage saurin kamuwa da benzylpenicillin suna da juriya. Yawancin rukunin D streptococci, anaerobic Gram-positive cocci da bacilli, gami da L. monocytogenes, Actinomyces spp. da Arachnia spp., suna da saukin kamuwa. Mycobacteria da nocardia suna jurewa.
Ampicillin yana da irin wannan aiki zuwa benzylpenicillin akan N. gonorrheae, N. meningitidis da Mor. catarrhal. Yana da sau 2-8 mafi aiki fiye da benzylpenicillin akan H. mura da kuma Enterobacteriaceae da yawa, amma nau'in samar da β-lactamase suna jurewa. Pseudomonas spp. suna da juriya, amma Bordetella, Brucella, Legionella da Campylobacter spp. suna sau da yawa masu saukin kamuwa. Wasu anaerobes marasa kyau na Gram kamar Prevotella melaninogenica da Fusobacterium spp. suna da saukin kamuwa, amma B. fragilis yana da juriya, kamar yadda mycoplasmas da rickettsiae suke.
Ayyuka a kan nau'in kwayoyin A β-lactamase-samar da nau'in staphylococci, gonococci, H. mura, Mor. catarrhalis, wasu Enterobacteriaceae da B. fragilis suna haɓaka ta kasancewar masu hana β-lactamase, musamman clavulanic acid.
Ayyukan bactericidal yana kama da na benzylpenicillin. Haɗin gwiwar ƙwayoyin cuta yana faruwa tare da aminoglycosides akan E. faecalis da enterobacteria da yawa, kuma tare da mecillinam akan yawancin enterobacteria masu jurewa ampicillin.
